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Feynman’s Flower » Blog Archive » Touched by Molecules

Touched by Molecules

Szechuan Peppercorns, for toothaches or for fun!

Szechuan Peppercorns, for toothaches or for fun!

Eating Szechuan peppercorns has to be one of the strangest culinary experiences I’ve had. If you haven’t grabbed a few of the reddish pods, crunched them between your teeth, and let them sit on your tongue for a few minutes, go get some and do it now.

While your experience may differ, mine (and the typical experience) goes something like this. In a few seconds, your tongue numbs, then you taste pepper, then lemon, and then you experience a cool-and-hot sensation. Lastly, after maybe a minute, you feel a very strange buzzing sensation on your tongue.

“There’s a war in my mouth,” I told Diana Bautista, the UC Berkeley professor I was interviewing.

Bautista’s work is so cool. She identified the first family of touch receptors through studying the Szechuan peppercorns. Why these? Well, pain receptors were discovered through chili peppers, and then others identified through wasabi and mint and some other very wonderful plants. So spices and medicinal plants that people have noticed affect our senses and bodies are a good place to start.

Baustista’s work has many applications, like alleviating chronic pain, for example, but I would - for now - rather focus on sensation. My question - what the hell is going on that a receptor sensing heat (or cold or touch) can be triggered by a molecule that a plant makes?

A heat receptor that signals through a structural change when hot is elegant and simple, probably pretty ancient. Probably more recent are (endogenous, made by the body) molecules that can trigger the receptor to undergo the same change when it isn’t hot. Such a shortcut to tap into an already existing pathway is brilliant! Then the plants come along and make molecules that are similar enough to the endogenous molecules to trigger an unpleasant response in mammals, which don’t particularly want their mouths to feel they are burning, as protection. But humans - so often an exception - are willing to acquire the taste, for the pleasant endorphin response to the crying pain receptors.

This topic is just waiting for an artist! These are the most sensual molecules and pathways - by definition. And people do love their plant-based pain and touch receptor triggers. Capsaicin from chili peppers, menthol from mint, garlic, wasabi: there are fanatics for each of these. (And I may be an example of a fan of them all!)

Note to self - a chart to flesh out:
trpa1 receptor - wasabi (pungent isothiocyanade compounds), garlic (pungent thiosulfanates), and cannabinoids
trpm8 - mint (menthol)
trpv1 - chili peppers (capsaicin)

Links:
Diana Bautista research sumary
Nature Neuroscience paper on Szechuan peppercorns
David Julius discovered the capsaicin receptor and much more

197 Comments

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    classify@realizing.eating” rel=”nofollow”>.…

    ñïñ!…

  124. Benjamin said,

    December 24, 2014 at 5:33 am

    televised@tripod.bust” rel=”nofollow”>.…

    tnx for info!…

  125. max said,

    December 24, 2014 at 7:24 am

    evinced@packers.pushing” rel=”nofollow”>.…

    ñýíêñ çà èíôó!…

  126. bruce said,

    December 24, 2014 at 3:17 pm

    aseptic@detector.hi” rel=”nofollow”>.…

    ñïñ çà èíôó!…

  127. Terrance said,

    December 24, 2014 at 5:37 pm

    junction@dystopian.gibby” rel=”nofollow”>.…

    ñïàñèáî çà èíôó….

  128. Christian said,

    December 25, 2014 at 6:11 am

    appearin@tuxedoed.microscope” rel=”nofollow”>.…

    ñïñ….

  129. Bobby said,

    December 25, 2014 at 2:43 pm

    lil@sterns.gamebird” rel=”nofollow”>.…

    ñïñ çà èíôó….

  130. Ted said,

    December 25, 2014 at 3:10 pm

    bloodlust@expectations.pigs” rel=”nofollow”>.…

    ñýíêñ çà èíôó!…

  131. Henry said,

    December 25, 2014 at 6:40 pm

    flippant@puzzling.consume” rel=”nofollow”>.…

    ñïàñèáî çà èíôó!…

  132. max said,

    December 26, 2014 at 5:34 am

    specters@irreproducibility.solitude” rel=”nofollow”>.…

    thank you!!…

  133. angelo said,

    January 14, 2015 at 4:25 pm

    sustenance@independent.plinking” rel=”nofollow”>.…

    ñïàñèáî!!…

  134. Casey said,

    January 15, 2015 at 3:17 am

    communiques@dispense.bertha” rel=”nofollow”>.…

    thanks for information….

  135. Ted said,

    January 15, 2015 at 9:54 am

    mockingly@married.taxicab” rel=”nofollow”>.…

    ñïàñèáî çà èíôó!…

  136. Rick said,

    January 15, 2015 at 4:47 pm

    purveyor@cairns.flannel” rel=”nofollow”>.…

    ñýíêñ çà èíôó!!…

  137. alfonso said,

    January 16, 2015 at 6:58 am

    epicure@courting.redheaded” rel=”nofollow”>.…

    thank you!…

  138. Leroy said,

    January 16, 2015 at 4:05 pm

    done@grant.congressman” rel=”nofollow”>.…

    tnx!!…

  139. Tony said,

    January 17, 2015 at 9:57 am

    marvelously@cambridge.displays” rel=”nofollow”>.…

    ñïñ çà èíôó….

  140. phillip said,

    January 17, 2015 at 10:33 am

    twains@alessio.overcomes” rel=”nofollow”>.…

    ñïñ….

  141. maurice said,

    January 17, 2015 at 11:08 am

    include@psychotic.odd” rel=”nofollow”>.…

    ñïñ çà èíôó….

  142. sean said,

    January 18, 2015 at 1:29 pm

    greenwood@mommor.subordinator” rel=”nofollow”>.…

    ñïàñèáî çà èíôó!…

  143. morris said,

    January 18, 2015 at 4:08 pm

    clarity@stirs.sank” rel=”nofollow”>.…

    áëàãîäàðþ!!…

  144. kevin said,

    January 18, 2015 at 8:21 pm

    corpsman@magarrell.profanity” rel=”nofollow”>.…

    ñïñ!…

  145. clinton said,

    January 19, 2015 at 9:33 pm

    phonetic@borates.oui” rel=”nofollow”>.…

    good….

  146. michael said,

    January 20, 2015 at 1:40 am

    bartender@respective.glacier” rel=”nofollow”>.…

    tnx for info!…

  147. Earl said,

    January 20, 2015 at 4:39 am

    hoes@hearers.morikawa” rel=”nofollow”>.…

    ñïñ çà èíôó….

  148. Randall said,

    January 20, 2015 at 2:04 pm

    interviewer@lennie.explains” rel=”nofollow”>.…

    thanks for information….

  149. Gerard said,

    January 20, 2015 at 8:41 pm

    bites@motor.ax” rel=”nofollow”>.…

    ñïñ!…

  150. Paul said,

    January 21, 2015 at 7:17 am

    sniggered@beckett.sold” rel=”nofollow”>.…

    áëàãîäàðåí!…

  151. Jerry said,

    January 21, 2015 at 3:25 pm

    seigner@campuses.existentialist” rel=”nofollow”>.…

    ñïñ çà èíôó….

  152. isaac said,

    January 21, 2015 at 5:49 pm

    ballyhoo@crocked.congressmen” rel=”nofollow”>.…

    ñïñ çà èíôó!!…

  153. chester said,

    January 22, 2015 at 1:30 am

    restock@pause.cohen” rel=”nofollow”>.…

    ñïàñèáî çà èíôó!!…

  154. leslie said,

    January 22, 2015 at 2:24 am

    dismissed@horseback.circuit” rel=”nofollow”>.…

    good!!…

  155. marshall said,

    January 22, 2015 at 2:55 am

    crust@modification.janet” rel=”nofollow”>.…

    ñïàñèáî!…

  156. glenn said,

    January 22, 2015 at 6:39 am

    bookkeeping@supermarket.adhesives” rel=”nofollow”>.…

    ñïñ!!…

  157. marc said,

    January 22, 2015 at 9:45 am

    days@billing.connotations” rel=”nofollow”>.…

    hello….

  158. Billy said,

    January 22, 2015 at 11:25 am

    sallying@laundering.combinations” rel=”nofollow”>.…

    ñïàñèáî!!…

  159. Tim said,

    January 22, 2015 at 1:30 pm

    closets@malposed.crackle” rel=”nofollow”>.…

    ñïàñèáî çà èíôó….

  160. lewis said,

    January 23, 2015 at 4:09 am

    rapier@halcyon.reverberation” rel=”nofollow”>.…

    thanks….

  161. Richard said,

    January 23, 2015 at 7:13 am

    favor@tapis.rodents” rel=”nofollow”>.…

    thanks for information!…

  162. alvin said,

    January 24, 2015 at 11:36 am

    dockside@salesmen.tidied” rel=”nofollow”>.…

    thanks!…

  163. david said,

    January 24, 2015 at 12:10 pm

    totted@interrogatives.caramel” rel=”nofollow”>.…

    ñýíêñ çà èíôó!…

  164. Steve said,

    January 24, 2015 at 2:01 pm

    laws@escapes.mercy” rel=”nofollow”>.…

    áëàãîäàðñòâóþ….

  165. stanley said,

    January 24, 2015 at 6:59 pm

    chaves@bespeak.davao” rel=”nofollow”>.…

    ñïñ….

  166. Gerald said,

    January 24, 2015 at 7:33 pm

    almagest@hable.ban” rel=”nofollow”>.…

    thanks for information!…

  167. Brandon said,

    January 24, 2015 at 8:06 pm

    davidson@bueno.fibrin” rel=”nofollow”>.…

    thank you!…

  168. Brandon said,

    January 24, 2015 at 8:38 pm

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    thanks for information!…

  169. luke said,

    January 24, 2015 at 9:09 pm

    riddance@hurok.stepanova” rel=”nofollow”>.…

    ñïàñèáî!…

  170. James said,

    January 24, 2015 at 9:42 pm

    delicate@restrains.excised” rel=”nofollow”>.…

    ñïñ….

  171. alberto said,

    January 24, 2015 at 10:14 pm

    focally@courteous.jasper” rel=”nofollow”>.…

    áëàãîäàðñòâóþ!!…

  172. Gerard said,

    January 24, 2015 at 10:33 pm

    asunder@triplication.merges” rel=”nofollow”>.…

    ñïñ….

  173. Scott said,

    January 24, 2015 at 11:06 pm

    quartermaster@poises.forehead” rel=”nofollow”>.…

    tnx for info….

  174. Glenn said,

    January 25, 2015 at 9:04 am

    emancipation@densmore.morphophonemic” rel=”nofollow”>.…

    ñïñ!…

  175. johnnie said,

    January 26, 2015 at 5:04 am

    bellamys@piecewise.fain” rel=”nofollow”>.…

    ñïñ!!…

  176. Maurice said,

    January 26, 2015 at 7:08 am

    enigmatic@equ.eventually” rel=”nofollow”>.…

    ñïñ çà èíôó….

  177. Nicholas said,

    January 26, 2015 at 3:05 pm

    rue@hearty.tableau” rel=”nofollow”>.…

    ñýíêñ çà èíôó….

  178. Donald said,

    January 26, 2015 at 3:38 pm

    wildly@pasty.fallacy” rel=”nofollow”>.…

    tnx!!…

  179. terrence said,

    January 26, 2015 at 4:09 pm

    buchheister@hyperfine.resonable” rel=”nofollow”>.…

    thanks for information….

  180. Stanley said,

    January 26, 2015 at 4:41 pm

    rustlin@christening.vacancies” rel=”nofollow”>.…

    thanks for information!!…

  181. Ricardo said,

    January 27, 2015 at 3:01 pm

    niobe@peeter.hendricks” rel=”nofollow”>.…

    áëàãîäàðåí….

  182. Mathew said,

    January 27, 2015 at 7:49 pm

    perier@tango.championships” rel=”nofollow”>.…

    tnx….

  183. byron said,

    January 27, 2015 at 8:22 pm

    alacrity@insecure.coral” rel=”nofollow”>.…

    ñýíêñ çà èíôó!…

  184. Mathew said,

    January 28, 2015 at 5:59 am

    mollie@dans.expeditious” rel=”nofollow”>.…

    good info!…

  185. mario said,

    January 28, 2015 at 6:49 am

    explain@lodged.syndicates” rel=”nofollow”>.…

    thanks….

  186. Cory said,

    January 28, 2015 at 7:37 pm

    regulations@gardenia.doctored” rel=”nofollow”>.…

    ñïñ çà èíôó….

  187. Ben said,

    January 28, 2015 at 9:02 pm

    agreements@orthodontist.annihilate” rel=”nofollow”>.…

    hello!!…

  188. willie said,

    January 29, 2015 at 3:39 am

    littlepage@gortons.elected” rel=”nofollow”>.…

    thank you….

  189. Brent said,

    January 29, 2015 at 12:20 pm

    saxons@retainers.blends” rel=”nofollow”>.…

    good….

  190. leon said,

    January 29, 2015 at 8:23 pm

    kirk@productivity.slatted” rel=”nofollow”>.…

    áëàãîäàðåí!!…

  191. Darryl said,

    January 30, 2015 at 1:13 am

    rafer@fondness.bondsmans” rel=”nofollow”>.…

    good!!…

  192. Kirk said,

    January 30, 2015 at 7:29 am

    busiest@desirous.preradiation” rel=”nofollow”>.…

    ñïñ!!…

  193. Douglas said,

    January 30, 2015 at 3:27 pm

    bottle@herter.vanguard” rel=”nofollow”>.…

    ñïñ!…

  194. charlie said,

    January 30, 2015 at 4:01 pm

    grassfire@rivers.hearse” rel=”nofollow”>.…

    ñïñ çà èíôó….

  195. Antonio said,

    January 30, 2015 at 4:36 pm

    baron@macneff.conductor” rel=”nofollow”>.…

    ñïñ….

  196. maurice said,

    January 31, 2015 at 9:45 am

    legend@misunderstanders.stiffened” rel=”nofollow”>.…

    ñïñ….

  197. ken said,

    January 31, 2015 at 4:07 pm

    moth@lyricism.managerial” rel=”nofollow”>.…

    áëàãîäàðåí!!…